New Kind Anti-estrogen Pharm Raw Powder Trilostane AntiCancer
Product Name: Trilostane
Synonym: 17-hydroxy-3-oxo-4,5-epoxyandrostane-2-carbonitrile; (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
CAS No.: 13647-35-3
Packing: foil bag
EINECS No.: 237-133-0
Appearance: White powder
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
Albuterol Sulfate/Ventolin powders/Proventil powders/CAS No: 51022-70-9
It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.
Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.
|Melting point||257°C to 270°C||261°C -266°C|
|Appearance||White to pale white solid||White solid|
|Heavy metals||No more than 20ppm||10ppm|
|Loss on drying||Not more than 0.5%||0.18%|
|Residue on Ignition||Not more than 0.1%||0.02%|
|Solubility||soluble in dimethyl sulfoxide||Conforms|
| ||soluble in pyridine||Conforms|
| ||slightly soluble in ethanol||Conforms|
| ||slightly soluble in water||Conforms|
|Assay (microbial)||Not less than 99.0%||99.5%|
|Related impurities||not more than 1.0%||0.35%|
|HPLC purity||not less than 99.0%||99.6%|
|Conclusion||Comply with In-house standard.|
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