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99% White Powder Progesterone 57-83-0 Oral Anabolic Steroids For Female Animal Pregnancy
Product Name: Progesterone
Synonyms: PROGESTERONE-WATER SOLUBLE;progestin;PROGESTERONE;PRIMOLUT;17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;17alpha-Progesterone;3,20-Pregnene-4;4-Pregnen-3,20-dion
Product Categories: MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;API;ENDOMETRIN;Plant extract;Pharma material;Inhibitors
Mol File: 57-83-0.mol
MP 128-132 °C(lit.)
alpha 186 º (c=1, ethanol)
refractive index 182 ° (C=2, Dioxane)
storage temp. Store at RT
solubility H2O: 25 mg/mL, may be clear to slightly hazy
Water Solubility <0.1 g/100 mL at 19 ºC
Stability: Stable. Incompatible with strong oxidizing agents.
Hazard Codes Xn,T,F
Risk Statements 40-45-62-36-20/21/22-11
Safety Statements 36/37-45-53-16
WGK Germany 3
Description of Progesterone :
Progesterone is a hormone released by luteal cells in the ovaries which contains 21 Carbon Atoms. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids. There are two crystal forms of progesterone, that are type-α and type-β, the two types have similar physiological activity. Type-α is precipitated from dilute ethanol as orthorhombic white prismatic crystal, while type-β is orthorhombic white needle crystal, they are both insoluble in water, but soluble in ethanol, ethyl ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
Progesterone can be released by the ovary, placenta and adrenal cortex. Its physiological function mainly manifests in promoting estrogen treated over thicken lining of the uterus to continue the development, proliferation and thickening and hypertrophy, soften and secretion of mucus in order to make good condition for implantation of the fertilized egg. After the implantation, early stage survival and development of fertilized egg is also under the control of the high progesterone release. As a result, progesterone is a very important hormone in the female reproductive system, and it is also an important intermediate in the biosynthesis of steroid hormones. All steroid hormone releasable glands can produce progesterone, but only ovarian and placenta can release progesterone as the main hormone. Ovarian will release large amount of progesterone in the luteal phase after ovulation by granulose luteal cells, so progesterone is also named as progestin. Progesterone will decrease in result of corpus luteum atrophy. For normal women, placenta will becomes the main organ maintain progesterone after 8 to 9 weeks of pregnancy, accompany with the ovary releasing until the end of pregnancy.
The main physiological effects of progesterone:
1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus.
2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function.
3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus.
4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands.
5. Progesterone is involved in the feedback regulation of the hypothalamus and anterior pituitary, which makes the balance of the animal reproductive hormones. In vivo, progesterone content of all sorts of livestock follicular phase is below 1 ng / ml, while in bovine corpus luteum period is approximately 4 ng / ml, pregnancy period is about 18 ng / ml.
Usage And Synthesis:
Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.
In the 40's, only chemical method can be used to monitor the excretion of pregnanediol which is the metabolism of progesterone in the urine of 24h, this could reflect the level of progesterone release.
Started from the 50's, progesterone levels in plasma could be determined not only by chemical methods, but also by biological methods and gas chromatography.
At the end of the 60's, radionuclides and protein competition were developed to determine progesterone.
In the 70's, the radiation immune assay and the radiation receptor method have appeared, which greatly improved the sensitivity and accuracy of the assay. When determination of progesterone in blood has been widely used, the determination of urinary progesterone has lost its importance. Normal value of follicular phase in urine was 1mg/24h, and in the corpus phase was 2-8mg/24h. Changes of progesterone levels in women of childbearing age can reflect the different stages of the menstrual cycle. For pregnant women, blood progesterone continued rising, which is not coincidence with the normal cycle. For the person of congenital 17α-hydroxylase deficiency syndrome, there is abnormal ratio of progesterone to 17α-Hydroxy progesterone, that is progesterone ascending while 17α-Hydroxy progesterone decreasing.
Preparation Products And Raw materials:
Raw materials Cyclohexanone-->16-Dehydropregnenolone acetate-->Aluminium isopropoxide-->Pregnenolone
Preparation Products Deoxycorticosterone acetate -->Dexamethasone-17-acetate-->17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate-->9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate-->9beta,11beta-epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate-->16,17-Epoxypregna-5,9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal)-->17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal-->16-Dehydroprogesterone
Q how can I be sure the powder contains right substances?
S We can offer you the cretificate of analysis of products and HPLC,Besides, After Receiving the goods, you can send it to detect, or buy a test kit steroid, detect it yourself.
Q What's the guarantees that you will send items after payment
S The feedback of customers:
Tracking Number :DHL3292172505
Yes,i have recieved it,really fast,good job,thanks.
-----Jean from France
We are regular company, we guarantee that after the receipt of your payment we will arrange the shipment within 24 hours , and provide the tracking number, you can keep track of it.so,don't hesitate to let me serve you.
Q What kind of payments does you support?
S T/T, , and Bitcion are accepted.
Q What’s the MOQ?
S Generally speaking, the MOQ is 10 gram, but we also can provide you samples for quality inspection.
Q Do you charge for the samples?
S According to our company policy, we just charge the samples based on EXW price. And we will return the samples fee during the next order.
Q Can you packing according to customers' requirements ?
S Sure,we will adopt safe and discreet package.If you have a request for packing, please tell us,Any good ideas are welcomed.
Q Can you tell me your main customers?
S That's our customer’s privacy, we should protect their information.
At the same time, please rest assured that your information is also safe here.
We'll offer you the quotation as soon as possible once receive your inquiry.
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