White Powder Prohormone Supplement Ingredient 976-71-6 Canrenone Acetate For Blood Mediation

Canrenone

Alias: 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
CAS NO:976-71-6
Molecular weight:340.46
Molecular formula:C22H28O3
Packing:Foil bag

Prohormone Supplement Ingredient Canrenone Acetate For Blood Mediation

Product Description

CAS: 976-71-6
M. F: C22H28O3
M. W: 340.46

Appearance: Pale yellow to pale Green Solid Powder
The properties of the aldosterone antagonists spironolactone and potassium canrenoate in tablet formulations were examined in two studies in healthy subjects, the first study comparing levels of their common major metabolite, canrenones, in plasma and the second study comparing the pharmacological activity of the two drugs in reversing the renal effects of the synthetic mineralocorticoid fludrocortisone.
At equal dosage by weight potassium canrenoate yielded peak levels and areas under the curve for canrenones in plasma which were significantly lower than those for spironolactone, and the peak level of canrenones was reached significantly later. Comparison with published work suggests that the experimental formulation of potassium canrenoate had low bioavailability.
Spironolactone produced statistically valid log dose-response curves against fludrocortisone as regards sodium excretion, potassium retention and increased urine sodium to potassium ratio. There was no significant log dose-reponse after potassium canrenoate, and a statistically valid estimate of relative potency could not be obtained.
The results of the two studies seem inconsistent with the view that canrenones alone is responsible for the pharmacological activity of both drugs, and suggest that a significant part of the activity of spironolactone may be attributable to metabolites other than canrenones.


Applications:

Canrenones (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.
It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.

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